That inhibit bacterial cell wall synthesis such

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{"type":"standard","title":"Waylon & Willie","displaytitle":"Waylon & Willie","namespace":{"id":0,"text":""},"wikibase_item":"Q7975949","titles":{"canonical":"Waylon_&_Willie","normalized":"Waylon & Willie","display":"Waylon & Willie"},"pageid":7425358,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/9/9a/JenningsNelsonWaylon%26Willie.jpg","width":316,"height":316},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/9/9a/JenningsNelsonWaylon%26Willie.jpg","width":316,"height":316},"lang":"en","dir":"ltr","revision":"1200211500","tid":"569acca1-be47-11ee-b1a5-959e770a1e89","timestamp":"2024-01-29T01:40:10Z","description":"1978 studio album by Waylon Jennings and Willie Nelson","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Waylon_%26_Willie","revisions":"https://en.wikipedia.org/wiki/Waylon_%26_Willie?action=history","edit":"https://en.wikipedia.org/wiki/Waylon_%26_Willie?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Waylon_%26_Willie"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Waylon_%26_Willie","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Waylon_%26_Willie","edit":"https://en.m.wikipedia.org/wiki/Waylon_%26_Willie?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Waylon_%26_Willie"}},"extract":"Waylon & Willie is a duet studio album by American singers Waylon Jennings and Willie Nelson, released by RCA Records in 1978. In the US, it stayed at #1 album on the country album charts for ten weeks and would spend a total of 126 weeks on the country charts.","extract_html":"

Waylon & Willie is a duet studio album by American singers Waylon Jennings and Willie Nelson, released by RCA Records in 1978. In the US, it stayed at #1 album on the country album charts for ten weeks and would spend a total of 126 weeks on the country charts.

"}

{"slip": { "id": 84, "advice": "Never set an alarm clock unless you know how to switch it off"}}

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{"type":"standard","title":"Treponema pallidum","displaytitle":"Treponema pallidum","namespace":{"id":0,"text":""},"wikibase_item":"Q156007","titles":{"canonical":"Treponema_pallidum","normalized":"Treponema pallidum","display":"Treponema pallidum"},"pageid":61836,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/2/29/Treponema_pallidum.jpg/330px-Treponema_pallidum.jpg","width":320,"height":301},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/2/29/Treponema_pallidum.jpg","width":531,"height":500},"lang":"en","dir":"ltr","revision":"1286446151","tid":"d677c97a-1d76-11f0-af10-1d0540d946ce","timestamp":"2025-04-19T23:34:29Z","description":"Species of bacterium","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Treponema_pallidum","revisions":"https://en.wikipedia.org/wiki/Treponema_pallidum?action=history","edit":"https://en.wikipedia.org/wiki/Treponema_pallidum?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Treponema_pallidum"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Treponema_pallidum","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Treponema_pallidum","edit":"https://en.m.wikipedia.org/wiki/Treponema_pallidum?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Treponema_pallidum"}},"extract":"Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel, and yaws. It is known to be transmitted only among humans and baboons. T. pallidum can enter the host through mucosal membranes or open lesions in the skin and is primarily spread through sexual contact. It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. T. pallidum's lack of both a tricarboxylic acid cycle and processes for oxidative phosphorylation results in minimal metabolic activity. As a chemoorganoheterotroph, Treponema pallidum is an obligate parasite that acquires its glucose carbon source from its host. Glucose can be used not only as a primary carbon source but also in glycolytic mechanisms to generate ATP needed to power the bacterium given its minimal genome. The treponemes have cytoplasmic and outer membranes. Using light microscopy, treponemes are visible only by using dark-field illumination. T. pallidum consists of three subspecies, T. p. pallidum, T. p. endemicum, and T. p. pertenue, each of which has a distinct related disorder. The ability of T. pallidum to avoid host immune defenses has allowed for stealth pathogenicity. The unique outer membrane structure and minimal expression of surface proteins of T. pallidum has made vaccine development difficult. Treponema pallidum can be treated with high efficacy by antibiotics that inhibit bacterial cell wall synthesis such as the beta-lactam antimicrobial penicillin-G.","extract_html":"

Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel, and yaws. It is known to be transmitted only among humans and baboons. T. pallidum can enter the host through mucosal membranes or open lesions in the skin and is primarily spread through sexual contact. It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. T. pallidum's lack of both a tricarboxylic acid cycle and processes for oxidative phosphorylation results in minimal metabolic activity. As a chemoorganoheterotroph, Treponema pallidum is an obligate parasite that acquires its glucose carbon source from its host. Glucose can be used not only as a primary carbon source but also in glycolytic mechanisms to generate ATP needed to power the bacterium given its minimal genome. The treponemes have cytoplasmic and outer membranes. Using light microscopy, treponemes are visible only by using dark-field illumination. T. pallidum consists of three subspecies, T. p. pallidum, T. p. endemicum, and T. p. pertenue, each of which has a distinct related disorder. The ability of T. pallidum to avoid host immune defenses has allowed for stealth pathogenicity. The unique outer membrane structure and minimal expression of surface proteins of T. pallidum has made vaccine development difficult. Treponema pallidum can be tre